Medical Immunology, 7e (HB)

This seventh edition of Medical Immunology, now in a full-color presentation, continues to provide a succinct clinical review of the human response to infection while being firmly grounded in science. The authors, distinguished and experienced educators, have been able to anticipate readers’ conceptual challenges and use illustrations, diagrams, and algorithms throughout to simplify complex concepts. With an emphasis on clinical applications, methodological advances, immunological diseases, and innovative interventions, this tried and true guide navigates readers through state-of-the-sciences technologies and demonstrates their implementation in the day-to-day clinical practice of immunology.

Key Features

• Stresses both the basic scientific concepts and clinical correlations to medical practice.
• Progresses logically from normal immune function to abnormalities and clinical diseases.
• Reviews the diagnosis, pathogenesis, and management of autoimmune diseases in a concise, manageable and visual manner
• Continues to be the only current medically-focused immunology text available
• Provides a succinct review of human response to infection with a focus on diagnostic and clinical immunology

About the Author

Gabriel Virella obtained his MD and PhD degrees at the University of Lisbon, Portugal, in 1967 and 1974. He did post-doctoral studies in Immunology at the Department of Experimental Pathology, University of Birmingham, England (1968-69) and at the National Institute for Medical Research, Mill Hill, London, England (1969-1970). From 1970 to 1975 was a Researcher at the Gulbenkian Institute of Science, Oeiras, Portugal. He moved to the Medical University of South Carolina (MUSC) in 1975, where he is an Emeritus Professor of Immunology and Microbiology. He has published 260 articles in topics related primarily to immunology, with particular emphasis on the involvement of autoimmune phenomena in the pathogenesis of atherosclerosis. He has described original techniques for the isolation and characterization of antigen-antibody complexes, immunoassays for tetanus and diphtheria antibodies, and for the assay of modified LDL and corresponding antibodies. In 1989 he was co-recipient with Drs. Christoph Gisinger and Maria F. Lopes Virella of the Squibb Award of the Austrian Society for Internal Medicine for the work entitled “Metabolic effects of Lipoprotein Immune Complexes in Macrophages”. He co-edited a first edition of “Introduction to Medical Immunology” in 1986, and became the single editor of the 3rd edition, in 1993. The 4 ed. (1999) was translated to the Italian. He has now edited the 7th Ed. of Medical Immunology. In addition, he published “NMS Microbiology and Infectious Diseases”, 3rd Ed, Williams&Wilkins, 1997; and NMS Q&A Microbiology, Immunology, and Infectious Diseases, Lippincott Williams & Wilkins, 1999. He was Section Editor of Clinical Immunology from 1989 to 2003. During his tenure at the Medical University of South Carolina he received numerous teaching awards from the students, the Health Science Foundation Teaching Excellence Award, MUSC in 1996 and 2006, Governor’s Distinguished Professor Award in 1996 and 2006, the National  Robert J. Glaser Distinguished Teacher Award in 2003, and cited as Cited as “Master Teacher” by the Board of Trustees of The Medical University of S.C. in 2007.

Table of Contents

Chapter 1: Introduction

Gabriel Virella

Chapter 2: Leucocytes and Lymphoid Tissues: The Framework of the Immune System

Gabriel Virella

Chapter 3: Major Histocompatibility Complex

Ellen Klohe and Janardan P. Pandey

Chapter 4: The Adaptive Immune Response: Antigens, Lymphocytes and Accessory Cells

Gabriel Virella and John Sleasman

Chapter 5: Immunoglobulins: Structure and Diversity

Gabriel Virella

Chapter 6: Immunoglobulins: Metabolism and Biological Properties

Gabriel Virella

Chapter 7: Genetics of Immunoglobulins: Ontogenic, Biological and Clinical Implications

Janardan P. Pandey

Chapter 8: Antigen-Antibody Reactions

Gabriel Virella

Chapter 9: The Complement System in Health and Disease

Carl Atkinson

Chapter 10: Monocyte and Lymphocyte Membrane Markers: Ontogeny and Clinical Significance

Scott Sugden, Damien Montamat-Sicotte, Karen Yam, Joseph Murphy, Bader Yassine Diab, and Virginia Litwin

Chapter 11: Cell-Mediated Immunity

José C. Crispín And Gabriel Virella

Chapter 12: Adaptive Humoral Immunity and Immunoprophylaxis

Gabriel Virella

Chapter 13: Phagocytic Cells and their Functions

Gabriel Virella And John Sleasman

Chapter 14: Anti-Infectious Innate and Adaptive Immune Responses

Carl Atkinson and Gabriel Virella

Chapter 15: Diagnostic Applications of Immunology

Ajay Grover, Virginia M. Litwin and Gabriel Virella

Chapter 16: Tolerance and Autoimmunity

George C. Tsokos and Gabriel Virella

Chapter 17: Organ-Specific Autoimmune Diseases

G. Virella and George C. Tsokos

Chapter 18: Systemic Lupus Erythematosus

George C. Tsokos

Chapter 19: Rheumatoid Arthritis

George C. Tsokos and Gabriel Virella

Chapter 20: Overview of Hypersensitivity

Gabriel Virella

Chapter 21: IgE-mediated (Immediate) Hypersensitivity

Albert F. Finn, Jr. and Gabriel Virella

Chapter 22: Immunohematology

Armand Glassman and Gabriel Virella

Chapter 23: The Pathogenic Role of Antigen-Antibody Complexes

Gabriel Virella and George C. Tsokos

Chapter 24: Immune System Modulators

Richard Silver and Stephen Elmore

Chapter 25: Transplantation Immunology

Satish N. Nadig and Jane C. Kilkenny

Chapter 26: Tumor Immunology

Juan Carlos Varela

Chapter 27: Lymphocyte and Plasma Cell malignancies

Juan Varela and Gabriel Virella

Chapter 28: Diagnosis of Immune Deficiency Diseases

John W. Sleasman and Gabriel Virella

Chapter 29: Primary Immunodeficiency Diseases

John Sleasman and Gabriel Virella

Chapter 30: AIDS and other Acquired Immunodeficiencies

John Sleasman and Gabriel Virella