Sickle Cell Disease

The most comprehensive, current sickle cell disease resource—for both clinicians and researchers

The first and only resource of its kind, Sickle Cell Disease examines this blood disorder through both clinical and research lenses. More than 80 dedicated experts in the field present their combined clinical knowledge of basic mechanisms, screening, diagnosis, management, and treatment of myriad complex complications of a single base point mutation in the human genome. Case studies with “How I Treat” authoritative insights provide overviews of common and rare complications, and Key Facts offer at-a-glance high-yield information.

Filled with clinical photos, illustrations, numerous original diagrams, and with free updates available online, this unmatched resource covers:

Mechanisms of sickle cell disease
Historic and current research approaches
The latest work in gene therapy and editing
Guidelines for patient care, diagnosis, unique cases, and therapies
Rare and common complications, including domestic and internationally relevant topics
Psychosocial and supportive care
The newest standards of therapy and future treatment options in children and adults
Cardiopulmonary complications

About the Author

Mark T. Gladwin, MD, is Professor and Chairman, Department of Medicine, University of Pittsburgh, and Director, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute.

Gregory J. Kato, MD, is Professor of Medicine, Division of Hematology/Oncology, University of Pittsburgh, and Director, University of Pittsburgh’s Sickle Cell Center of Excellence.

Enrico M. Novelli, MD, is Associate Professor of Medicine, Division of Hematology/Oncology, University of Pittsburgh, and Director, University of Pittsburgh Medical Center’s Adult Sickle Cell Disease Program.